Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.

Effects of pharmacological inactivation of adenosine 2A receptors in a murine model of polymicrobial sepsis

Sepsis is a worldwide health problem with an enormous economic burden and devastatingly high mortality rate. The pathophysiology and immune dysfunctions that occur during sepsis remain largely unknown, severely limiting current treatment options for sepsis. Both the innate and adaptive parts of the immune system are known to be involved in the dysfunctions that occur during sepsis. Over the las...

Involvement of adenosine in the antiinflammatory action of ketamine.

BACKGROUND Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and to reduce mortality and the production of tumor necrosis factor alpha and interleukin 6 in septic animals. Similarly, adenosine was shown to reduce tumor necrosis factor alpha and mortality of septic animals. The aim of this study was to determine w...

CEREBRAL BLOOD FLOW REGULATION IN ANESTHETIZED MORPHINE DEPENDENT RATS: THE ROLE OF THE ADENOSINE SYSTEM

Adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. In this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (MDR) using the laser Doppler flowmetry technique. Adult male Sprague Dawley rats (250-350 ...

Sepsis Survival in Mice Phagocytosis and Improves Polymicrobial Macrophage-Mediated Bacterial A2B Adenosine Receptor Blockade Enhances

Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs

Objective(s): For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). Materials and Methods: Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretr...